PR87341

HILLSBORO, Ore., Dec. 21, 2020 /PRNewswire=KYODO JBN/ --

- New instrument overcomes cryo-EM barriers, implements artificial intelligence

to deliver unparalleled ease-of-use at an affordable price

Thermo Fisher Scientific, the world leader in serving science, today announced

the new Thermo Scientific Tundra Cryo Transmission Electron Microscope

(Cryo-TEM), a groundbreaking instrument that extends cryo-electron microscopy

(cryo-EM) to more scientists by delivering industry-leading ease of use at an

affordable price.

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The Tundra uses artificial intelligence (AI), guided automation and new loader

technology to dramatically simplify the microscope's use, extending cryo-EM to

researchers of any experience level. The integrated cryo-loading station

replaces previous manual manipulation, enabling quick, effortless and robust

sample loading and transfer to the microscope for immediate assessment and

structure determination. Tundra also delivers a compact footprint that fits

most of today's standard-sized labs, eliminating the need for potential

renovations. In addition, it's offered at a lower price-point, making it

possible for more institutions and pharmaceutical companies to obtain

structural insights at a biologically relevant resolution.

"Cryo-EM is speeding the path to disease understanding and treatment. However,

many institutions find these instruments to be out of reach because of cost and

because they are too complex for new researchers," said Trisha Rice, vice

president and general manager of life sciences at Thermo Fisher Scientific. "We

worked with cryo-EM luminaries to develop an instrument that not only delivers

results, but, more importantly, brings cryo-EM to more users."

The Tundra simplifies cryo-EM in several ways. It offers:

    * AI and guided automation that help non-experts quickly identify the

      quality of their samples and easily navigate an otherwise complex

      workflow. As the sample moves through the cryo-EM process, the

      results are displayed in a "traffic light" style that helps

      scientists quickly determine if their sample is viable.

    * An integrated loader that makes it easier to load samples into the

      microscope than conventional systems. Scientists can exchange

      sample carriers in about two minutes. This allows researchers to

      rapidly optimize biochemistry sample conditions as results can be

      checked immediately.

    * Resolutions as high as 3.5 angstrom with throughput within 24 to 72 hours.

Cryo-EM has revolutionized structural biology research in just five years,

after being named the Nature Method of the Year 2015

https://c212.net/c/link/?t=0&l=en&o=3017562-1&h=881580253&u=https%3A%2F%2Fwww.nature.com%2Farticles%2Fnmeth.3730%23%3A%7E%3Atext%3DThe%2520time%2520is%2520right%2520to%2Cif%2520not%2520impossible%252C%2520to%2520crystallize.&a=Nature+Method+of+the+Year+2015 ). This method allows

scientists to drive impactful research, and three luminaries in the cryo-EM

field won the Nobel Prize in Chemistry 2017

https://c212.net/c/link/?t=0&l=en&o=3017562-1&h=2404870349&u=https%3A%2F%2Fwww.nobelprize.org%2Fprizes%2Fchemistry%2F2017%2Fpress-release%2F&a=Nobel+Prize+in+Chemistry+2017 ) for their foundational work

on this technique.

Thermo Fisher continues to advance cryo-EM innovation to help drive scientific

discovery, speeding the path to disease understanding and treatment. The Tundra

rounds out the Thermo Scientific portfolio of cryo-TEMs by offering an

affordable instrument for users of all experience levels. It joins the Thermo

Scientific Glacios Cryo-TEM,

https://c212.net/c/link/?t=0&l=en&o=3017562-1&h=3103519184&u=https%3A%2F%2Fwww.thermofisher.com%2Fus%2Fen%2Fhome%2Felectron-microscopy%2Fproducts%2Ftransmission-electron-microscopes%2Fglacios-cryo-tem.html&a=Thermo+Scientific+Glacios+Cryo-TEM%2C ) a versatile solution for

mid-range cryo-EM single particle analysis (SPA) and the Thermo Scientific Krios Cryo-TEM,

https://c212.net/c/link/?t=0&l=en&o=3017562-1&h=2397129945&u=https%3A%2F%2Fwww.thermofisher.com%2Fus%2Fen%2Fhome%2Felectron-microscopy%2Fproducts%2Ftransmission-electron-microscopes%2Fkrios-g4-cryo-tem.html&a=Thermo+Scientific+Krios+Cryo-TEM ) a powerful TEM designed for

ultimate performance and productivity. All three cryo-TEMs can be used independently

or together, enabling researchers to match the right instrument to their research needs.

To learn more about the Tundra, please visit: https://ter.li/Tundra.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science, with

annual revenue exceeding $25 billion. Our Mission is to enable our customers to

make the world healthier, cleaner and safer. Whether our customers are

accelerating life sciences research, solving complex analytical challenges,

improving patient diagnostics and therapies or increasing productivity in their

laboratories, we are here to support them. Our global team of more than 75,000

colleagues delivers an unrivaled combination of innovative technologies,

purchasing convenience and pharmaceutical services through our industry-leading

brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher

Scientific, Unity Lab Services and Patheon. For more information, please visit:

www.thermofisher.com

Media Contact Information:

Kathy Gill

Thermo Fisher Scientific

+1-971-294-9262

kathy.gill@thermofisher.com

SOURCE: Thermo Fisher Scientific