Zymo Research Releases Open-Source Bioinformatics Pipeline for SARS-CoV-2 Variant Detection in Wastewater
PR89454
IRVINE, Calif., May 11, 2021 /PRNewswire=KYODO JBN/ --
-- Early Release of the VirSieve(TM) Bioinformatics Pipeline Will
Promote Collaboration in Environmental SARS-CoV-2 Research
Zymo Research has released the VirSieve(TM) Bioinformatics Pipeline (
) source code to the environmental microbiology community to promote global
collaboration and support for the detection of SARS-CoV-2 variants in
wastewater. VirSieve(TM) is an automated computational pipeline that analyzes
sequencing reads from the SARS-CoV-2 virus in wastewater samples to better
understand viral variants present in monitored communities. By rating the
confidence interval in observed viral mutations, the software has the potential
to significantly increase the accuracy of analyzing any changes in the viral
genetic material.
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According to the Centers for Disease Control and Prevention, while the
deployment of vaccines has had a tremendous positive impact on curbing the
SARS-CoV-2 pandemic within the USA, new viral strains are still emerging. Some
of these strains, e.g., B.1.1.7, are classified as "variants of concern" due to
evidence of increased spread, pathogenicity, or vaccine evasion. Wastewater
Next-Gen Sequencing is emerging as the most viable solution for near real-time
community surveillance.
Viral sequencing from wastewater is difficult due to fragmentation and
degradation of the viral RNA, often resulting in sequencing errors that
ultimately manifest as false mutations. VirSieve(TM) can identify these false
variants and mark them as being low or no confidence, allowing researchers to
filter mutations with a higher degree of support. Zymo Research also provides
DNA/RNA Shield(TM) (
), a reagent that safeguards viral RNA from further degradation after
inactivation of any virus for safe, ambient temperature collection and
transportation of wastewater samples.
"Zymo Research has previously developed public software tools like the Zymo
Research Transmit Program, an open-source client for submitting COVID-19 test
results through the CalREDIE public health reporting system," said Dr. Michael
Weinstein, Director of Laboratory Information Systems, and Project Lead on the
VirSieve(TM) Pipeline project at Zymo Research. "VirSieve(TM) is part of Zymo
Research's ongoing effort to provide maximum support to pandemic response
efforts around the globe. We feel VirSieve(TM) has the potential to be used not
only for tracking variant strains of the SARS-CoV-2 virus in wastewater but
other viruses as well, for future public health efforts."
"Getting accurate variants from clinical samples or sewage is key to proper
placement of a viral strain in the context of all other viral variants and
informing pathogen tracking efforts," said Dr. Christopher Mason, who is a paid
speaker for Zymo Research and is the co-director of the WorldQuant Institute
for Quantitative Prediction and a professor of physiology and biophysics at
Weill Cornell Medicine.
For more information about the VirSieve(TM) Pipeline visit Zymo Research's
website (
) or contact them via email at tech@zymoresearch.com.
About Zymo Research Corp.
Zymo Research is a privately owned company that has been serving the scientific
and diagnostics community with state-of-the-art molecular biology tools since
1994. "The Beauty of Science is to Make Things Simple" is their motto, which is
reflected in all of their products, from epigenetics to DNA/RNA purification
technologies. Historically recognized as the leader in epigenetics, Zymo
Research is breaking boundaries with novel solutions for sample collection,
microbiomic measurements, diagnostic devices, and NGS technologies that are
high quality and simple to use. Follow Zymo Research on Facebook (
), LinkedIn (
), Twitter (
), and Instagram (
).
For more information about Zymo Research's COVID-19 products, check out the
following links:
- Zymo Research Releases Free Software to Streamline COVID-19 Test Reporting
(
)
- Zymo Research Obtains CE IVD Mark for its Quick SARS-CoV-2 Multiplex Kit (
)
- Zymo Research Obtains Emergency Use Authorization from FDA for Their Quick
SARS-CoV-2 rRT-PCR Kit (
)
- Zymo Research Receives CE IVD Mark for its Quick-DNA/RNA(TM) Viral MagBead
Kit (
)
- Zymo Research Launches COVID-19 Sequencing Service for the Detection and
Surveillance of Emerging SARS-CoV-2 Variants (
)
- Zymo Research Offers Community-Wide SARS-CoV-2 Detection and Variant
Tracking with the Environ(TM) COVID-19 Wastewater Testing Service (
)
- Zymo Research Receives 510(k) Clearance for its Collection/Transport Device
for COVID-19 (
)
Source - Zymo Research Corp.
CONTACT: Marketing Department, Zymo Research Corp., 949.679.1190,
marketing@zymoresearch.com
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