PR89750

BOLOGNA, Italy and HUNTINGDON VALLEY, Pa., May 27, 2021 /PRNewswire=KYODO JBN/ --

DEPArray(TM) PLUS – the new automated and versatile platform to investigate

pre-selected rare cell populations from various samples with 100% purity, now

enhanced with 9 fluorescent channels and remarkably improved user experience

Menarini Silicon Biosystems, a pioneer of liquid biopsy and single cell

technologies, announced today the launch of the new highly automated

DEPArray(TM) PLUS+, now available with 9 fluorescent channels. This robust

image-based cell-sorting technology combines microelectronics and microfluidics

in a unique platform to isolate rare cells from mixed cellular samples. Its

optimized, intuitive interface allows researchers to obtain the desired target

cells with a 100% purity and minimal operator interaction. The built-in

software leads to a rapid selection of cells with a high level of accuracy,

reproducibility, and quality images thanks to its fluorescent microscope

resolution. The system is compatible with a variety of rare cell suspensions,

including live and fixed cells, small cell loads, Formalin-Fixed

Paraffin-Embedded (FFPE) tissues and liquid biopsies. Sorting of rare cells

with DEPArray PLUS has become more effortless and precise than ever before.

DEPArray PLUS additional fluorescent channels provide expanded capabilities to

better characterize different cell populations from complex heterogeneous

samples. Once individual or pools of cells are isolated, researchers can

conduct precise molecular investigations. "The DEPArray PLUS can complement the

CELLSEARCH(R) platform, the Gold Standard for circulating tumor cells

enrichment, to perform further molecular analyses and clinical research using

the captured CTCs, since it features a unique automated workflow to isolate

cells with very limited operator intervention and improved standardization of

the process," commented Professor Leon WMM Terstappen, MD, PhD, Chair of the

Department of Medical Cell BioPhysics at the University of Twente, The

Netherlands.

DEPArray PLUS is the latest evolution of the DEPArray technology with unique

new features to optimize the user experience, reduce hands-on time and speed up

sample processing. These include an automated notification system informing

users directly on their mobile device upon the completion of each step of a run

and a faster workflow thanks to a new cartridge with enhanced microfluidics and

the implementation of pre-set parameters for identification and recovery of

target cells.

Researchers have the flexibility to prepare their samples according to their

own protocol or use optimized sample preparation kits for various inputs

including blood, FFPE tissue and forensic evidence. The system is able to

identify and isolate extremely low numbers of target cells from a minimal input

sample volume. DEPArray PLUS is fully integrated with blood samples prepared

with the Menarini Silicon Biosystems CTC enrichment technologies, CELLSEARCH(R)

and CELLMAG(TM), allowing further isolation and delivery of 100% pure single

cells ready for genetic analysis.

For Fabio Piazzalunga, President and CEO of Menarini Silicon Biosystems "We are

proud to provide the new powerful version of DEPArray technology for rare cell

sorting with full automation capability: it is a revolutionary platform on

which we will continue to add innovative features thereby opening new horizons

for patient-centered precision therapies"

About DEPArray(TM) PLUS

DEPArray(TM) PLUS is an automated, image-based platform combining fluorescence

and brightfield microscopy  to digitally sort target cells with 100% purity.

This proprietary technology allows the gentle sorting of single rare cells from

different samples such as enriched blood, FFPE tissues and forensic mixtures.

The image gallery provides high resolution information to review, select and

sort target cells for subsequent molecular characterization. The key new

features of the system lie in the expanded 9 fluorescent channels, improved

automation, faster single cell recovery and enhanced user experience.

For more information please refer to www.siliconbiosystems.com/deparray-plus.

About Menarini Silicon Biosystems

Menarini Silicon Biosystems offers unique rare cell technologies and solutions

that provide clinical researchers with access to unparalleled resolution in the

study of cells and their molecular characterization.

Menarini Silicon Biosystems [

https://c212.net/c/link/?t=0&l=en&o=2974193-1&h=2883067015&u=http%3A%2F%2Fwww.siliconbiosystems.com%2F&a=Menarini+Silicon+Biosystems

], based in Bologna, Italy, and Huntingdon Valley, Pa., U.S., is a wholly owned

subsidiary of the Menarini Group, a multinational pharmaceutical, biotechnology

and diagnostics company headquartered in Florence, Italy, with more than 17,000

employees in 140 countries.

+For research use only. Not for use in diagnostic procedures.

Contact:  Linda Pavy -  linda.pavy@bcw-global.com

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Source: Menarini Silicon Biosystems