International Team Led by BGI Completes First Whole-Body Cell Atlas of a Non-Human Primate
PR95480
SHENZHEN, China, April 14, 2022 /PRNewswire=KYODO JBN/ --
The research will provide insights into the development of potential treatments
for neurological diseases and obesity, among other human conditions.
In a breakthrough that could lead to scientific advancement in the treatment of
human diseases, researchers from BGI-Research, together with scientific
research teams from China, Germany, Italy, Singapore, Spain, Sweden and the UK,
today published the world's first non-human primate whole-body cell
transcriptomic atlas in the scientific journal
Nature(https://www.nature.com/articles/s41586-022-04587-3).
By using BGI's independently-developed DNBelab C4 single-cell library platform,
the researchers from BGI, Jilin University, Guangzhou Institutes of Biomedicine
and Health (Chinese Academy of Sciences), and 32 other international
institutions completed the single-cell transcriptome of 45 tissues and organs
from long-tailed macaque (cynomolgus) monkeys, obtaining a total of 1.14
million single-cell data and identifying 113 major cell types. The study, "Cell
transcriptomic atlas of the non-human primate Macaca fascicularis", obtained
ethical clearance before it was conducted.
This study and other large scale primate research at the single-cell level are
only possible through developments in advanced sequencing technology, an area
where BGI is a leader. BGI's proprietary technology enables extensive and
multi-dimensional single-cell analysis with high sensitivity and accuracy at a
low cost.
"Single-cell research is transforming our understanding of tissue and organ
functions at a cellular level, which informs how diseases develop and how they
can be treated," said Dr. Liu Longqi from BGI-Research, one of the
corresponding authors of the paper. "Having a whole-body organ single-cell map
of the adult macaque will significantly improve the ability to pinpoint how to
develop potential treatments for human diseases with greater precision."
By mapping the macaque transcriptome at the single-cell level, scientists now
have a database, or single-cell library, that can be used for
-developing methods for human disease diagnosis and treatment,
-assessment of clinical drug efficacy,
-analysis of cell evolution among species, and
-analysis of advanced cognitive functions of the brain.
"By understanding cell types and their characteristics, scientists will be able
to predict the impact of disease treatments on specific cell structures and
thus develop more targeted approaches for single-gene or complex genetic
diseases," said co-corresponding author Dr. Xu Xun, director of BGI-Research.
Source: BGI Group
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