Researchers discover how damaged DNA is repaired
A research group led by Waseda's Professor Hitoshi Kurumizaka and Assistant Professor Akihisa Osakabe has discovered the mechanism by which DNA damaged by ultraviolet (UV) light is recognized for repair.
2015-12-8
Waseda University
Researchers discover how damaged DNA is repaired
A research group led by Waseda's Professor Hitoshi Kurumizaka and Assistant Professor Akihisa Osakabe has discovered the mechanism by which DNA damaged by ultraviolet (UV) light is recognized for repair.
This year three scientists were awarded the Nobel Prize in Chemistry for mapping at a molecular level how damaged DNA was repaired. Nucleotide excision repair is a multistep process that repairs UV-damaged DNA and safeguards genetic information. Building on that research, the group led by Kurumizaka and Osakabe discovered that UV-damaged DNA was very flexible, and that UV-DDB, the surveillance protein in nucleotide excision repair, recognizes the damaged DNA structure within chromatin. This discovery will advance the understanding of skin cancer in xeroderma pigmentosum patients with a gene mutation caused by deficiencies in nucleotide excision repair and provide key information for new treatments of skin cancer.
Collaborators on this research include Associate Professor Wataru Kagawa (Meisei University), Professor Kaoru Sugasawa (Kobe University), Professor Shigenori Iwai (Osaka University), Professor Fumio Hanaoka (Gakushuin University), and Dr. Nicolas H. Thoma (Group Leader at Friedrich Miesher Institute for Biomedical Research).
This research was published in Scientific Reports (Nature Publishing Group) under the title "Structural basis of pyrimidine-pyrimidone (6-4) photoproduct recognition by UV-DDB in the nucleosome."
本プレスリリースは発表元が入力した原稿をそのまま掲載しております。また、プレスリリースへのお問い合わせは発表元に直接お願いいたします。
このプレスリリースには、報道機関向けの情報があります。
プレス会員登録を行うと、広報担当者の連絡先や、イベント・記者会見の情報など、報道機関だけに公開する情報が閲覧できるようになります。
このプレスリリースを配信した企業・団体
- 名称 早稲田大学
- 所在地 東京都
- 業種 大学
- URL https://www.waseda.jp/top/
過去に配信したプレスリリース
試行錯誤で学んだことで起きてしまう判断のバイアスは世界共通
6/28 11:00
下水を用いる感染症対策の経済価値
6/27 14:00
尿に極微量含まれる子宮頸がんウイルスタンパク質の検出に成功
6/25 14:00
音楽ライブの観客が「同期」するメカニズム
6/20 14:00
文理融合で社会実装 言語教育のAI活用を支える言語テスト妥当性研究の真髄
6/6 14:00
話者同士でつくりあう「共話」型コミュニケーションのデザインに向けて
6/4 14:00
軍事組織に対する文民統制と市民の信頼の因果関係を検証
6/4 10:00
物質中の創発磁気モノポールが示す新規な集団振動現象を発見
6/3 14:00
不規則なガラス構造に隠された規則性
5/13 14:24