KAZIA TO PRESENT FINAL DATA FROM PAXALISIB PHASE II STUDY IN GLIOBLASTOMA AT ESMO
PR97729
SYDNEY, Sept. 9, 2022 /PRNewswire=KYODO JBN/ --
Kazia Therapeutics Limited (NASDAQ: KZIA; ASX: KZA), an oncology-focused drug
development company, today announced that final data from its phase II study of
paxalisib in patients with newly diagnosed glioblastoma will be the subject of
an oral presentation at the upcoming annual congress of the European Society
for Medical Oncology (ESMO), which will be held in person from 9-13 September
2022 in Paris, France.
The oral presentation will summarise key findings of the completed phase II
study of paxalisib in glioblastoma, which was previously the subject of a
poster presentation at the American Society for Clinical Oncology (ASCO) Annual
Meeting in Chicago, IL, in June 2022. The presentation will provide additional
detail on pharmacokinetics and pharmacodynamics. The presentation will be
delivered by Professor John de Groot, Division Chief of Neuro-Oncology at the
University of California, San Francisco, one of the principal investigators on
the study.
ORAL PRESENTATION
Title: Pharmacokinetics and pharmacodynamics of paxalisib in newly diagnosed
glioblastoma patients with unmethylated MGMT promoter status: Final phase II
study results.
Date: Friday, 9 September
Session: CNS Tumours
Abstract ID: 2800
For More Information, Please Contact:-
In the United States:
Joe Green
Edison Investor Relations
jgreen@edisongroup.com
Phone: +1 646-653-7030
In Australia:
Jane Lowe
IR Department
jane.lowe@irdepartment.com.au
Phone: +61 411 117 774
About Kazia Therapeutics Limited
Kazia Therapeutics Limited (NASDAQ: KZIA; ASX: KZA) is an oncology-focused drug
development company, based in Sydney, Australia.
Our lead program is paxalisib, a brain-penetrant inhibitor of the PI3K / Akt /
mTOR pathway, which is being developed to treat glioblastoma, the most common
and most aggressive form of primary brain cancer in adults. Licensed from
Genentech in late 2016, paxalisib commenced recruitment to GBM AGILE, a pivotal
study in glioblastoma, in January 2021. Seven additional studies are active in
various forms of brain cancer. Paxalisib was granted Orphan Drug Designation
for glioblastoma by the US FDA in February 2018, and Fast Track Designation for
glioblastoma by the US FDA in August 2020. In addition, paxalisib was granted
Rare Pediatric Disease Designation and Orphan Designation by the US FDA for
DIPG in August 2020, and for AT/RT in June 2022.
Kazia is also developing EVT801, a small-molecule inhibitor of VEGFR3, which
was licensed from Evotec SE in April 2021. Preclinical data has shown EVT801 to
be active against a broad range of tumour types and has provided compelling
evidence of synergy with immuno-oncology agents. A phase I study commenced
recruitment in November 2021.
For more information, please visit www.kaziatherapeutics.com or follow us on
Twitter @KaziaTx.
This document was authorized for release to the ASX by James Garner, Chief
Executive Officer, Managing Director.
SOURCE Kazia Therapeutics Limited
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