PR99955

SEOUL, South Korea and NOTTINGHAM, England, April 19, 2023 /PRNewswire=KYODO JBN/ --

-'Daewoong Pharmaceutical enters research collaboration to discover a novel

small molecule to target autoimmune diseases using fragment-based drug

discovery and virtual high throughput screening

Daewoong Pharmaceutical has entered a research collaboration with Sygnature

Discovery to expand its global open innovation for novel drug development.

On the 18th April, Daewoong Pharmaceutical (CEO Seng-ho Jeon and Lee Chang-jae)

has announced a research collaboration with Sygnature Discovery (CEO Simon

Hirst), a global integrated drug discovery company, to discover a novel small

molecule to target autoimmune diseases.

Sygnature Discovery will provide its proprietary Fragment-Based Drug Discovery

(FBDD) and virtual high throughput screening (vHTS) to accelerate Daewoong's

novel drug discovery for autoimmune diseases. Additionally, Daewoong will

receive support in protein science and crystallography to validate and secure

mechanism of action. Through this collaboration, Daewoong Pharmaceutical

expects to broaden its drug discovery scope to the field of protein-protein

interaction (PPI) as a part of next-generation drug discovery strategy.

Sygnature Discovery is an integrated drug discovery company established in 2004

to support early drug development and clinical trials. Based in Nottingham,

United Kingdom, the company provides intellectual input and drug discovery

expertise to accelerate target validation, hit identification, hit-to-lead,

lead optimisation and drug discovery programmes. The company's capabilities

include medicinal chemistry, in vitro and in vivo biology, HTS, computational

chemistry and informatics, DMPK, form and formulation and protein

crystallography. Sygnature Discovery has a market-leading track record in drug

discovery including 22 compounds delivered into the clinic (Phases I to III)

since 2011, 41 compounds into pre-clinical development and over 170 patent

applications with Sygnature Discovery scientists named as inventors.

Simon Hirst, CEO of Sygnature Discovery, commented that "We are delighted to be

working with the talented team of scientists at Daewoong Pharmaceutical on this

integrated drug discovery collaboration" and added that "Sygnature has built an

FBDD platform which combines proprietary fragment collections with

high-throughput biophysical screening technologies to rapidly identify and

characterize fragment hits. We look forward to applying this technology along

with our specialist in silico-based virtual high-throughput screening (vHTS)

techniques to identify high value hits and leads and accelerate the novel small

molecule discovery process for Daewoong."

Park Joon-seok, head of Daewoong's drug discovery center commented that "We are

actively pursuing open collaborations on various innovative platform

technologies to boost global new drug discovery. We believe the collaboration

with Sygnature Discovery will set a new milestone in expanding Daewoong

Pharmaceutical's new drug pipeline."

[Clarification1] Fragment-Based Drug Discovery, FBDD

As the latest process of new drug development, it is a method of finding a lead

substance using a fragment compound (molecular weight less than 200) A fragment

compound with high binding ability to the target of a new drug is first

selected, and the binding position of the fragment compound is confirmed

through protein structure crystallography before the compound is constructed

using medicinal chemistry and precursors can be found through structural

chemistry to secure both patentability and novelty.

[Clarification2] Virtual Screening, VS

Virtual search is a computer-assisted technology used in discovering new drugs.

Using a computer library containing information on the structure of various

compounds, it is possible to identify substances that are most likely to bind

to drug targets. It is a technology that can accelerate the development of new

drugs by securing various predictive data on drug similarity, binding force,

binding state, etc. for the possibility of millions of compounds in a short

time as much as it utilizes computers.

[Clarification3] vHTS

Instead of many HTS evaluations performed to confirm the effectiveness of new

drug candidates, it obtains efficacy prediction results for virtually hundreds

of millions of compounds by introducing various calculation formulas and

existing results for the effectiveness of compounds. As it is predictive

technology, it is necessary to check the actual results, but it is being used

to accelerate the development of new drugs by culling hundreds of millions of

compounds to the level of 100 to 1000.

About Daewoong Pharmaceutical. Co., Ltd.

Established in 1945, Daewoong Pharmaceutical Co., Ltd. is a leading South

Korean pharmaceutical company that develops, manufactures, and commercializes

pharmaceuticals for both domestic and international markets. With a strong and

innovative in-house R&D and advanced manufacturing facilities, Daewoong

provides a total healthcare solution to customers across the globe. Continuing

on their course of building a strong global healthcare company, Daewoong has

broadened international operations by establishing branch offices and research

centers throughout Asia and the United States. Daewoong has also expanded

strategic partnerships in more than 100 countries worldwide.

In 2022, Daewoong expanded its global market presence by entering into a

license agreement worth USD 923 million, which granted permission for the use

of 'Fexuclue', a medicine licensed for the treatment of gastroesophageal reflux

disease, in the Philippines and Ecuador within the first year of its launch.

Additionally, Daewoong successfully launched 'Envlo', the first-ever sodium

glucose cotransporter 2 (SGLT2) inhibitor for the treatment of diabetes to be

developed in Korea, and signed an export contract worth USD 84.36 million with

Brazil and Mexico. For further information on Daewoong Pharmaceutical, please

visit our official website(https://www.daewoong.co.kr/en/main/index).

About Sygnature Discovery:

Sygnature Discovery is a world-leading integrated drug discovery partner,

offering expertise across a broad range of therapeutic areas and biological

target classes. Based in Nottingham and with facilities in Alderley Park,

Tytherington and Glasgow, employing close to 700 people.

For more information, visit: www.sygnaturediscovery.com.

SOURCE: Daewoong Pharmaceutical Co., Ltd.