Merck Enters into Further Global Co-Development and Commercialization Agreement for PARP Inhibitor with Chinese R&D Company BeiGene

AsiaNet 54979

DARMSTADT, Germany, Nov. 13, 2013 /PRN=KYODO JBN / --

    - New agreement marks the second collaboration between Merck and BeiGene

    Merck Serono, the biopharmaceutical division of Merck, today announced that

a global licensing, co-development, and commercialization agreement for

BeiGene-290 has been signed with BeiGene Co., Ltd., a biotech research and

development company in Beijing, China. The compound, which is a potent poly

(ADP-ribose) polymerase (PARP) inhibitor for the treatment of cancer, is

currently in preclinical development and is expected to enter clinical

development next year. This is the second collaboration agreement between the

two companies this year.

    PARP inhibitors are thought to target an enzyme family, poly (ADP-ribose)

polymerase, which is involved in a number of cellular processes, including DNA

repair and programmed cell death.

    Under the terms of the collaboration, BeiGene will be responsible for the

development and commercialization of BeiGene-290 in China, and Merck will be

responsible for the development and commercialization of BeiGene-290 for the

rest of the world. BeiGene will receive an undisclosed upfront payment and is

eligible to receive further payments of up to EUR 170 million (US$ 232 million)

for the achievement of clinical development and potential commercial milestones

in both the People's Republic of China and rest of the world, as well as

royalties on net sales.

    "We are delighted to announce an expansion of our strategic partnership

with BeiGene. Today's announcement highlights our commitment both to

establishing strong R&D partnerships in China but also to our partner BeiGene,

a preeminent Chinese life sciences company focused on discovering and

developing innovative oncology drugs," said Dr. Susan Jane Herbert, Head of

Global Business Development and Strategy for Merck Serono, the

biopharmaceutical division of Merck.

    John Oyler, CEO of BeiGene said: "We are very much looking forward to

expanding further our collaboration with Merck to include BeiGene-290. This

collaboration helps to accelerate the global development and commercialization

of this China-discovered oncology innovation, something BeiGene could not have

achieved alone. Furthermore this deal and Merck's previous deal with BeiGene to

develop the second generation, China-discovered BRAF inhibitor, BGB-283,

demonstrate Merck's deep commitment to China and external innovation."

    Both companies were recently awarded the 2013 BayHelix-Elsevier Award for

Alliance of the Year. This award recognizes a ground-breaking pharmaceutical

collaboration agreement involving a Chinese entity-one that is centered on

advancing the future of science and pharmaceutical innovation. It is a

significant recognition for both organizations, underscoring a shared

commitment to establishing strategic partnerships that accelerate the delivery

of differentiated new therapies to people living with serious unmet medical

needs.

    About BeiGene (Beijing), Co., Ltd.

    BeiGene is a Chinese novel R&D oncology company focusing on discovering,

developing and commercializing innovative oncology therapeutics. With a team of

around 150 scientists and staff, its pipeline is comprised of novel oral small

molecules and monoclonal antibodies for cancer. BeiGene Ltd. is a Cayman

Islands exempted company that is an investor in and collaborator with BeiGene

(Beijing), Co. Ltd.

    For more information please visit: http://www.beigene.com.

    About Merck Serono

    Merck Serono is the biopharmaceutical division of Merck. With headquarters

in Darmstadt, Germany, Merck Serono offers leading brands in 150 countries to

help patients with cancer, multiple sclerosis, infertility, endocrine and

metabolic disorders as well as cardiovascular diseases. In the United States

and Canada, EMD Serono operates as a separately incorporated subsidiary of

Merck Serono.

    Merck Serono discovers, develops, manufactures and markets prescription

medicines of both chemical and biological origin in specialist indications. We

have an enduring commitment to deliver novel therapies in our core focus areas

of neurology, oncology, immuno-oncology and immunology.

    For more information, please visit http://www.merckserono.com.

    All Merck Press Releases are distributed by e-mail at the same time they

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    Merck is a leading pharmaceutical, chemical and life science company with

total revenues of EUR 11.2 billion in 2012, a history that began in 1668, and a

future shaped by approx. 38,000 employees in 66 countries. Its success is

characterized by innovations from entrepreneurial employees. Merck's operating

activities come under the umbrella of Merck KGaA, in which the Merck family

holds an approximately 70% interest and free shareholders own the remaining

approximately 30%. In 1917 the U.S. subsidiary Merck & Co. was expropriated and

has been an independent company ever since.

    SOURCE: Merck Serono